Download Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles by Kevin H. Shaughnessy,Engelbert Ciganek,Rebecca B. PDF

By Kevin H. Shaughnessy,Engelbert Ciganek,Rebecca B. DeVasher,Scott E. Denmark

The metal-catalyzed amination of aryl and alkenyl electrophiles has built right into a well-known technique for the synthesis of common items, energetic pharmaceutical elements, agricultural chemical compounds, and fabrics for molecular electronics. Copper catalysts advertise the coupling of quite a lot of nitrogen nucleophiles, together with amines, amides, and heteroaromatic nitrogen compounds with aryl and alkenyl halides. The reactivity profile of copper catalysts is complementary to that of palladium catalysts in lots of situations. Copper catalysts are powerful with much less nucleophilic nitrogen nucleophiles, corresponding to amides and azoles, while palladium catalysts are more advantageous with extra nucleophilic amine nucleophiles. Copper is an enticing replacement to palladium because of its considerably lower price. additionally, excessive job palladium catalysts require dear and infrequently air-sensitive ligands, while the trendy copper platforms use really reliable and cheap diamine or amino acid ligands. Copper-catalyzed C?N coupling reactions are tolerant of a variety of useful teams and feature been utilized to the synthesis of numerous complicated usual items. major paintings has additionally been performed to appreciate the mechanism of those reactions. present mechanistic realizing of those methodologies is roofed during this monograph.

The contents of the booklet are taken from the great evaluation of the subject within the natural Reactions sequence. optimum experimental stipulations for the amination of aryl and alkenyl halides with all periods of nitrogen nucleophiles are provided. particular experimental strategies from the literature are supplied for the key periods of copper-catalyzed C?N coupling reactions. A tabular survey of all examples of Cu-catalyzed arylation and alkenylation of nitrogen nucleophiles is gifted in 35 tables prepared by means of nitrogen nucleophile and electrophilic coupling partner.

The literature is roofed via December 2015 and gives three hundred fresh citations to complement the 680 citations of the unique hardbound bankruptcy. those most up-to-date literature references were accumulated in separate sections in accordance with the series of the tables within the tabular survey part. In all the sections, the person citations were prepared in alphabetic order of the writer names.
Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles is meant to supply natural chemists with an obtainable, yet certain, advent to this crucial type of transformations.

Show description

Read Online or Download Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles PDF

Best physical & theoretical chemistry books

Business Education in Emerging Market Economies: Perspectives and Best Practices

Company schooling in rising marketplace Economies discusses the effect of commercial schooling on rising markets and explores curricular innovation, pedagogical ways, and strategic alliances within the context of industrializing economies. rising markets comprise eighty% of the world's inhabitants and a few seventy five% of its alternate development within the foreseeable destiny, based on the U.

Kinetics of Phase Transitions

Delivering a finished creation with the mandatory historical past fabric to make it available for a large clinical viewers, Kinetics of section Transitions discusses  advancements in domain-growth kinetics. This booklet combines pedagogical chapters from prime specialists during this region and specializes in incorporating a variety of experimentally correct effects—such as ailment, pressure fields, and wetting surfaces—into stories of section ordering dynamics.

Nanocrystalline Materials: Their Synthesis-Structure-Property Relationships and Applications (Elsevier Insights)

This moment version of Nanocrystalline fabrics offers up-to-date details at the improvement and experimental paintings at the synthesis, houses, and functions of nanocrystalline fabrics. Nanocrystalline fabrics with new functionalities express nice promise to be used in business functions — resembling reinforcing fillers in novel polymer composites — and gigantic development has been made long ago decade of their synthesis and processing.

Nanotechnologie (Farbe und Lack Edition) (German Edition)

Die chemische Nanotechnologie ist die gezielte Herstellung von Systemen, Materialien oder Komponenten mit nanoskaligen Abmessungen durch chemische Synthese. Die Autoren liefern mit diesem Buch einen Überblick über alle wichtigen Felder der chemischen Nanotechnologie. Mit Beispielen aus der Glaschemie, der Silikonchemie und der Festkörperchemie, wird der Leser immer Schritt für Schritt zu den komplexeren Reaktionen der anorganisch-organischen Nanokomposite geführt.

Additional info for Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles

Example text

Download PDF sample

Rated 4.30 of 5 – based on 10 votes